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We Can Print You a New Bone 

And four other lessons we learned from local schools this year

click to enlarge JEFF DREW
  • Jeff Drew

Let’s say you took a dive at your local roller rink and wound up in the hospital with a fractured vertebra in your spine. You’re in big trouble — these things don’t exactly heal themselves.

Or at least they didn’t used to.

click to enlarge SCHOLASTIC.susmitabose.jpg

Thanks to a tricked-out desktop printer and a little applied chemistry conducted at Washington State University in Pullman, doctors may soon be able to take CT scans of busted spines, jaws and teeth and then print out — within as little as two days — perfect threedimensional replicas, ready to install. Not only that, but the new bones would act as a kind of scaffolding for your body’s own bone tissue, ultimately dissolving to give way to the real thing.

The jaw-dropping, sci-fi nature of the feat garnered the university attention from publications around the world when it got out last year. Dr. Susmita Bose, the lead researcher on the project, smiles proudly as she types her name into Google and pulls up story after story from the BBC, NBC, the Huffington Post.

The chemical part of Bose’s astounding project is actually relatively simple. Bose and her team of researchers — many of them WSU students — have for years been creating ceramic out of calcium phosphate (one of the main ingredients in human bone) and doping it with trace elements of other stuff that’s already found in the body — magnesium, zinc, silicon, etc. The material is bone-like in its strength, and the “dopants” added to it make it more biocompatible, allowing it to dissolve in the body without negative effect. (The biggest challenge has been regulating how quickly it dissolves, as a spinal injury takes significantly longer to heal after surgery than, say, a jaw dislocation.)

The trickier part — and the problem they had to solve first — was how to turn that calcium phosphate into an actual three dimensional object. While 3D printing has been around for years, the printer they bought online was built to produce metals. Bose says it took a year or two to tweak the machine for their purposes.

“Basically, 3D printing is nothing but you draw the picture on a computer, send that file to the machine, and the machine builds the part according to your drawing,” she says.

“So, how perfect the final part is matching with your drawing, that is something that’s going to require optimization to achieve the desired part.”

That part is made up of hundreds of layers of the calcium phosphate material, each laid down by the printer along with a kind of adhesive spray to hold it all together. When the part is finished printing, within a matter of hours, it’s then dried and densified, to make sure it’s solid and strong.

The results are extraordinary. Bose produces a pink plastic box that looks like an oversized pill organizer. In each snap-tight compartment are examples of their work: a trio of small, slender hip stems; a series of off-white mesh cylinders; even a few small, buttonshaped, bas-relief renderings of the WSU cougar logo.

But the most impressive is a tiny replica of a pelvis, about the size of your fingertip, complete with sacrum, ilium, coccyx. The detail is unbelievable.

“Yes, exactly! The detail, right?” Bose says with pride. “The detail of that was so perfect.”

Of course, the project is far from over. Asked when she thought she would be finished, Bose smiles and sighs.

“It’s never really finished,” she says.

She’s happy that her team has arrived at the point it has, but they still need to fine-tune the mechanism, and they need to put it into the hands of the biomedical industry in order to get it manufactured and distributed to hospitals.

The next goal, she believes, will be a bonelike scaffolding that not only provides the structure needed for healing but could also actually distribute drugs into the site to speed bone growth, thus taking an active role in the recovery process.

In the meantime, she and her colleague and husband, Dr. Amit Bandyopadhyay, are working on printing metals for use in body parts that need to bear heavier loads — say, the femur in your leg — and coating them with doped calcium phosphate to help the bone “take.”

But as Tron as all of this is, Bose takes the big-picture view of her work.

“Though we are very excited to do this research, I must say this,” she notes, lowering her head in a kind of reverential sigh. “It doesn’t matter how great we are doing in science and engineering and research — we all must have respect for Mother Nature. And it is very difficult to mimic nature.”

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